Guadalupe Baños *

Autora invitada por SIIC

Se evalúan niveles de enzimas antioxidantes en un modelo de síndrome metabólico

ENZIMAS ANTIOXIDANTES EN DOS ETAPAS PATOLOGICAS DE RATAS ALIMENTADAS CON SACAROSA

En un modelo de síndrome metabólico, la edad, el sexo y el tratamiento con sacarosa favorecen el incremento en el estrés oxidativo. En las hembras, los niveles de las actividades de enzimas antioxidantes tienden a ser menores que en los machos, pero los estrógenos posiblemente los compensan.

*Guadalupe Baños
describe para SIIC los aspectos relevantes de su trabajo
ACTIVITIES OF ANTIOXIDANT ENZYMES IN TWO STAGES OF PATHOLOGY DEVELOPMENT IN SUCROSE-FED RATS
Institución principal de la investigación
*Instituto Nacional de Cardiología ?Ignacio Chávez?, Ciudad de México, México, México, México
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Referencias bibliográficas
1. Bohnen N, Degenaar CP, Jolles J. 1992. Influence of age and sex on 19 blood variables in healthy subjects. Z Gerontol 25:339-345.
2. Holvoet P, Kritchevsky SB, Tracy RP, Mertens A, Rubin SM, Butler J, Goodpaster B, Harris TB. 2004. The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort. Diabetes 53:1068-1073.
3. Lichnovska R, Gwozdziewiczova S, Hrebicek J. 2002. Gender differences in factors influencing insulin resistance in elderly hyperlipemic non-diabetic subjects. Cardiovasc Diabetol 1:4.
4. McCarthy JJ, Meyer J, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ. 2003. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. Hum Genet 114(1):87-98.
5. Wirfalt E, Hedblad B, Gullberg B, Mattisson I, Andren C, Rosander U, Janzon L, Berglund Gl. 2001. Food patterns and components of the metabolic syndrome in men and women: a cross-sectional study within the Malmo Diet and Cancer cohort. Am J Epidemiol 154:1150-1159.
6. Ford ES, Mokdad AH, Giles WH, Brown DW. 2003. The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes 52:2346-2352.
7. Reaven G, Ho H. 1991. Sugar-induced hypertension in Sprague-Dawley rats. Am J Hypertens 4:610-614.
8. El Hafidi M, Baños G. 1997. In vivo plasma lipid oxidation in sugar-induced rat hypertriglyceridemia and hypertension. Hypertension 30:624-628.
9. Baños G, Medina Campos ON, Maldonado PD, Zamora J, Pérez I, Pavón N, Pedraza Chaverri J. 2005. Antioxidant enzymes in hypertensive and hypertriglyceridemic rats. Effect of gender. Clin Exp Hypertens 1:45-57.
10. Cárdenas G, Torres JC, Zamora J, Pérez, Baños G. 2005. Isolated heart function after ischemia and reperfusion in sucrose-fed rats. Influence of gender and treatment. In press.

Otros artículos de Guadalupe Baños

Baños G, Carvajal K, Cardoso G, Zamora J, Franco M. Vascular reactivity and effects of serum in a rat model of hypertension and hypertriglyceridemia. Am J Hypertens 1997; 10:379-388.

El Hafidi M, Baños G. In vivo plasma lipid oxidation in sugar-induced rat hypertriglyceridemia and hypertension. Hypertension 1997; 30(part 2):624-628.

Nava P, Guarner V, Posadas R, Pérez I, Baños G. Insulin-induced endothelin release and vasoreactivity in hypertriglyceridemic and hypertensive rats. Am J Physiol 1999, 277:H399-H404.

Carvajal K, El Hafidi M, Baños G. Myocardial damage due to ischemia and reperfusion in hypertriglyceridemic and hypertensive rats: participation of free radicals and calcium overload. J Hypertens 1999; 17:1607-1616.

El Hafidi M, Valdez R, Baños G. Possible relationship between altered fatty acid composition of serum, platelets and aorta and hypertension induced by sugar feeding in rats. Clin Exper Hypertens 2000; 22(1):99-108.

Baños G, El Hafidi M, Franco M. Oxidative stress and cardiovascular physiopathology. Curr Topics Pharmacol 2000; 5:1-17.

El Hafidi M, Cuéllar A, Ramírez J, Baños G. Effect of sucrose addition to drinking water that induced hypertension in the rats on liver microsomal and 5-desaturase activities. J Nutritional Biochem 2001; 12(7):396-403.

Carvajal K, Baños G. Myocardial function and effect of serum in isolated heart from hypertriglyceridemic and hypertensive rats. Clin Exper Hypertens 2002; 24(4):235-248.

Carvajal K, Baños G, Moreno Sánchez R. Impairment of glucose metabolism and energy transfer in the hypertriglyceridemic rat heart. Mol Cell Biochem 2003; 249:157-165.

El Hafidi M, Pérez I, Zamora J, Soto V, Carvajal Sandoval G, Baños G. Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. Am J Physiol Regul Integr Comp Physiol 2004; 287:R1387-R1393.

Baños G, Medina Campos OE, Maldonado PD, Zamora J, Pérez I, Pavón N, Pedraza Chaverrí J. Antioxidant enzymes in hypertensive and hypertriglyceridemic rats. Effect of gender. Clin Exper Hypertens 2005; 1:45-56.

Cárdenas G, Torres J C, Zamora J, Baños G. Isolated heart function during ischemia and reperfusion in sucrose-fed rats. Effect of insulin infusion. Cardiovascular Pathology. 2005; 14:256-264.

Para comunicarse con Guadalupe Baños mencionar a SIIC como referencia:
gbanos@yahoo.com

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Acerca del trabajo completo

ENZIMAS ANTIOXIDANTES EN DOS ETAPAS PATOLOGICAS DE RATAS ALIMENTADAS CON SACAROSA

Título original en castellano
ACTIVIDADES DE ENZIMAS ANTIOXIDANTES EN DOS ETAPAS DE PATOLOGIA DESARROLLADA EN RATAS ALIMENTADAS CON SACAROSA

Autores
Guadalupe Baños¹, Omar Medina Campos², Perla Maldonado³, José Zamora⁴, Israel Pérez⁵, Natalia Pavón⁶
1 Investigador, Instituto Nacional de Cardiología “Ignacio Chávez”, Investigador en Ciencias Médicas
2 Investigador, Universidad Autónoma de México (UNAM), Investigador
3 Investigador, Universidad Autónoma de México (UNAM), Investigador
4 Investigador, Instituto Nacional de Cardiología, Investigador
5 Investigador, Instituto Nacional de Cardiología , Investigador
6 Investigadora, Instituto Nacional de Cardiología , Investigadora

Acceso a la fuente original
Canadian Journal of Physiology and Pharmacology
http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp

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