Dahir Ramos de Andrade Júnior *

Autor invitado por SIIC

O trabalho procura reunir o conhecimento atual sobre a influência genética na evolução crônica das hepatites virais.

A INFLUÊNCIA DO GENOMA HUMANO NO CURSO DAS HEPATITES VIRAIS CRÔNICAS

Os estudos genéticos realizados em pacientes com hepatite viral crônica têm contribuído para o entendimento da sua patogênese. Vários alelos MHC foram correlacionados com evolução clínica mais favorável em pacientes com hepatite viral crônica B e C. Neste sentido, foram identificados em vários estudos 5 alelos relacionados com melhor evolução da hepatite viral B crônica, e cerca de 23 alelos foram correlacionados com melhor evolução da hepatite viral C crônica. Por outro lado, alguns estudos mostram correlação entre alelos específicos e um curso clínico menos favorável das hepatites virais crônicas B e C. A determinação da correlação entre genes específicos e a evolução das hepatites virais crônicas B e C, constitui o primeiro passo para o entendimento da patogênese dessas doenças. O próximo passo será correlacionar estes genes com respostas imunes específicas. Estes achados serão úteis no futuro para o desenvolvimento de estratégias terapêuticas apropriadas para controlar as hepatites virais, bem como melhorar o nosso conhecimento sobre os fatores determinantes do prognóstico dessas doenças. Um maior número de estudos genéticos, envolvendo diferentes populações, é necessário para que mais genes específicos que influenciam a evolução das hepatites virais crônicas possam ser identificados.

*Dahir Ramos de Andrade Júnior
describe para SIIC los aspectos relevantes de su trabajo
THE INFLUENCE OF THE HUMAN GENOME ON CHRONIC VIRAL HEPATITIS OUTCOME
Institución principal de la investigación
*Laboratório de Investigação Médica 54, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 470, Prédio IMT, Brasil, São Paulo, Brasil
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Referencias bibliográficas
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Para comunicarse con Dahir Ramos de Andrade Júnior mencionar a SIIC como referencia:
dahira@uol.com.br

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A INFLUÊNCIA DO GENOMA HUMANO NO CURSO DAS HEPATITES VIRAIS CRÔNICAS

Título original en castellano
A INFLUÊNCIA DO GENOMA HUMANO NO CURSO DAS HEPATITES VIRAIS CRÔNICAS

Autores
Dahir Ramos de Andrade Júnior¹, Dahir Ramos de Andrade²
1 Médico, Laboratório de Investigação Médica 54, Faculdade de Medicina, Universidade de São Paulo, Médico Assistente/professor Associado
2 Médico, Laboratório de Investigação Médica 54, Faculdade de Medicina, Universidade de São Paulo, Médico Assistente/chefe Responsável

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Revista do Instituto de Medicina Tropical de São Paulo
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