Carolina Andrea Pontillo *

Autora invitada por SIIC

Este trabajo representa una contribución significativa a la comprensión del mecanismo molecular de acción de un pesticida organoclorado como el Hexaclorobenceno en la carcinogénesis mamaria

ACTIVACIÓN DE LAS VÍAS DE SEÑALIZACIÓN DE C-SRC/HER1/STAT5B Y HER1/ERK1/2 Y DE LA MIGRACIÓN CELULAR POR HEXACLOROBENCENO EN LA LÍNEA CELULAR DE CARCINOMA MAMARIO HUMANO MDA-MB-231

Demostramos que el pesticida organoclorado Hexaclorobenceno estimula la migración celular y las vías de señalización c-Src/HER1/STAT5b y HER1/ERK1/2 en la línea de carcinoma mamario humano MDA-MB-231. Observamos que c-Src, HER1 y el Receptor de Hidrocarburos Aromáticos (AhR) están involucrados en la acción del pesticida sobre la migración celular. Este trabajo representa una contribución significativa a la comprensión del mecanismo molecular de acción del HCB en la carcinogénesis mamaria.

*Carolina Andrea Pontillo
describe para SIIC los aspectos relevantes de su trabajo
ACTIVATION OF C-SRC/HER1/STAT5B AND HER1/ERK1/2 SIGNALING PATHWAYS AND CELL MIGRATION BY HEXACHLOROBENZENE IN MDA-MB-231 HUMAN BREAST CANCER CELL LINE
Institución principal de la investigación
*Universidad de Buenos Aires, Buenos Aires, Argentina
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Otros artículos de Carolina Andrea Pontillo

1)”Hexachlorobenzene induces cell proliferation and IGF-I signaling pathway in an estrogen receptor α-dependent manner in MCF-7 breast cancer cell line.”. María Alejandra García, Delfina Peña, Laura Alvarez, Claudia Cocca, Carolina Pontillo, Rosa Bergoc, Diana Kleiman de Pisarev y Andrea Randi. Toxicology Letters 192: 195-205. (2010).

2)“Hexachlorobenzene triggers apoptosis in rat thyroid follicular cells”. Florencia Chiappini, Laura Alvarez, Victoria Lux-Lantos, Andrea S. Randi, Diana L. Kleiman de Pisarev. Toxicological Sciences 108(2):301-310. (2009).

3)“Hexachlorobenzene triggers AhR translocation to the nucleus, c-Src activation and EGFR transactivation in rat liver”. Randi Andrea, Marcela Susana Sánchez, Laura Alvarez, Julián Cardozo, Carolina Pontillo, Diana Kleiman de Pisarev. Toxicology Letters 177: 116-122 (2008).

4)“Hexachlorobenzene is a tumor Co-carcinogen and induces alterations in Insulin Growth Factors Signaling Pathway in the Rat Mammary Gland”. Randi, Andrea S, Cocca C, Carbone V, Nuñez M, Croci M, Gutierrez A, Bergoc R, Kleiman de Pisarev DL.
Toxicological Sciences 89 (1): 83-92 (2006).

5) “Hexachlorobenzene-induced early changes in Ornithine decarboxylase and Protein Tyrosine Kinase activities, Polyamines and c-Myc, c-Fos and c-Jun proto-oncogenes in rat liver”. Randi, Andrea S.; Hernández, S.; Alvarez, L.; Sánchez, M.; Schwarcz, M.; and D.L. Kleiman de Pisarev. Toxicological Sciences 76: 291-298 (2003).
6) “Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity and phosphotyrosine content in rat liver”. Andrea S.Randi, H.A.Sancovich, A.M.Ferramola de Sancovich, A.Loaiza, R.Kölliker Frers,, F.Spinelli, and D.L.Kleiman de Pisarev. Biochemical Pharmacology vol 65 (9) 1495-1506 (2003).
7) “Reproductive effects of Hexachlorobenzene in female rats”. L.Alvarez, Andrea Randi, P.Alvarez, G.Piroli, A.Chamson-Reig, V.Lux-Lantos, and Kleiman de Pisarev, DL. J. of Applied Toxicology, 20, 81-87 (2000).

8)- “Effect of Hexachlorobenzene on NADPH-generating lipogenic enzymes and L-glycerol-3-phosphate dehydrogenase in brown adipose tissue”. L.Alvarez, Andrea Randi, P.Alvarez, R.Kolliker Frers, and D.L.Kleiman de Pisarev. J. of Endocrinological Investigation, 22, 436-445 (1999).
9)-“Hexachlorobenzene, a dioxin type compound, increase Malic Enzyme gene transcription through a mechanism involving the thyroid hormone response element”. A.Loaiza Pérez, M.T.Seisdedos, D.L. Kleiman de Pisarev, H.A.Sancovich, Andrea S.Randi, A.M.Ferramola de Sancovich and P.Santisteban. Endocrinology, 140, 4142- 4151 (1999).

10) “Hexachlorobenzene-induced alterations of rat hepatic microsomal membrane function”. Andrea S.Randi, H.A.Sancovich, A.M.Ferramola de Sancovich, A.Loaiza, L.Krawiec and D.Kleiman de Pisarev. Toxicology 125, 83-94 (1998).ISSN: 0300-483X

Para comunicarse con Carolina Andrea Pontillo mencionar a SIIC como referencia:
andybiol@yahoo.com.ar

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Acerca del trabajo completo

ACTIVACIÓN DE LAS VÍAS DE SEÑALIZACIÓN DE C-SRC/HER1/STAT5B Y HER1/ERK1/2 Y DE LA MIGRACIÓN CELULAR POR HEXACLOROBENCENO EN LA LÍNEA CELULAR DE CARCINOMA MAMARIO HUMANO MDA-MB-231

Título original en castellano
ACTIVACION DE LAS VIAS DE SEÑALIZACION DE C-SRC/HER1/STAT5B Y HER1/ERK1/2 Y DE LA MIGRACION CELULAR POR HEXACLOROBENCENO EN LA LINEA CELULAR DE CARCINOMA MAMARIO HUMANO MDA-MB-231

Autores
Carolina Andrea Pontillo¹, María Alejandra García², Delfina Peña³, Claudia Cocca⁴, Florencia Chiappini⁵, Laura Alvarez⁶, Diana Leonor Kleiman De Pisarev⁷, Andrea Silvana Randi⁸
1 Bióloga, Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, Becaria Doctoral del Conicet
2 Bióloga, Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, Becaria de Grado
3 Bióloga, Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, Becaria de Grado
4 Bioquímica, Laboratorio de Radioisótopos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires., Profesora Asociada; Investigadora Adjun
5 Bióloga, Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, Becaria Doctoral Dl Conicet
6 Bióloga, Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, Jefe de Trabajos Prácticos
7 Química, Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, Profesora Adjunta e Investigadora Indep
8 Bióloga, Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, Jefe de Trabajos Prácticos e Investigado

Acceso a la fuente original
Toxicological Sciences
http://www.toxsci.oupjournals.org

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