Ingrid Morales *

El trabajo propone la acumulación de glutamato en astrocitos nomo un mecanismo para la excitotoxicidad en las enfermedades de los ganglios basales

EL ESTRIADO EN EL ORIGEN Y LA PROGRESIÓN DE LA ENFERMEDAD DE PARKINSON.

La liberación excesiva de glutamato estriatal (inducida por una reducción de dopamina en la enfermedad de Parkinson) es recaptada por astrocitos donde genera una inhibición de la glutamina sintetasa. Esta inhibición desencadena una acumulación persistente de glutamato en astrocitos (semanas) cuya liberación podría generar excitotoxicidad de gran intensidad.

*Ingrid Morales
describe para SIIC los aspectos relevantes de su trabajo
SELF-INDUCED ACCUMULATION OF GLUTAMATE IN STRIATAL ASTROCYTES AND BASAL GANGLIA EXCITOTOXICITY
Institución principal de la investigación
*Departamento de Fisiología, Facultad de Medicina, Universidad de la Laguna, la Laguna, Tenerife, Islas Canarias, España Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (ciberned), ,
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Referencias bibliográficas
Andre VM, Cepeda C, Levine MS. 2010. Dopamine and glutamate in Huntington's disease: A balancing act. CNS Neurosci Ther 16:163-78

Halliday GM, Stevens CH. 2011. Glia: initiators and progressors of pathology in Parkinson's disease. Mov Disord 26:6-17

Hazell AS. 2007. Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies. Neurochem Int 50:941-53

Matute C, Domercq M, Sanchez-Gomez MV. 2006. Glutamate-mediated glial injury: mechanisms and clinical importance. Glia 53:212-24

McGeer PL, McGeer EG. 2008. Glial reactions in Parkinson's disease. Mov Disord 23:474-83

Morales I, Fuentes A, Gonzalez-Hernandez T, Rodriguez M. 2009. Osmosensitive response of glutamate in the substantia nigra. Exp Neurol 220:335-40

Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G. 2010. Missing pieces in the Parkinson's disease puzzle. Nat Med 16:653-61

Rappold PM, Tieu K. 2010. Astrocytes and therapeutics for Parkinson's disease. Neurotherapeutics 7:413-23

Rodriguez Diaz M, Alonso TJ, Perdomo Diaz J, Gonzalez Hernandez T, Castro Fuentes R, Sabate M, Garcia Dopico J. 2005. Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra. Glia 49:134-42

Sofroniew MV, Vinters HV. 2010. Astrocytes: biology and pathology. Acta Neuropathol 119:7-35

Swanson RA, Ying W, Kauppinen TM. 2004. Astrocyte influences on ischemic neuronal death. Curr Mol Med 4:193-205

Teismann P, Schulz JB. 2004. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res 318:149-6

Vesce S, Rossi D, Brambilla L, Volterra A. 2007. Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. Int Rev Neurobiol 82:57-71

Xu J, Peng H, Kang N, Zhao Z, Lin JH, Stanton PK, Kang J. 2007. Glutamate-induced exocytosis of glutamate from astrocytes. J Biol Chem 282:24185-97
Andre VM, Cepeda C, Levine MS. 2010. Dopamine and glutamate in Huntington's disease: A balancing act. CNS Neurosci Ther 16:163-78

Halliday GM, Stevens CH. 2011. Glia: initiators and progressors of pathology in Parkinson's disease. Mov Disord 26:6-17

Hazell AS. 2007. Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies. Neurochem Int 50:941-53

Matute C, Domercq M, Sanchez-Gomez MV. 2006. Glutamate-mediated glial injury: mechanisms and clinical importance. Glia 53:212-24

McGeer PL, McGeer EG. 2008. Glial reactions in Parkinson's disease. Mov Disord 23:474-83

Morales I, Fuentes A, Gonzalez-Hernandez T, Rodriguez M. 2009. Osmosensitive response of glutamate in the substantia nigra. Exp Neurol 220:335-40

Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G. 2010. Missing pieces in the Parkinson's disease puzzle. Nat Med 16:653-61

Rappold PM, Tieu K. 2010. Astrocytes and therapeutics for Parkinson's disease. Neurotherapeutics 7:413-23

Rodriguez Diaz M, Alonso TJ, Perdomo Diaz J, Gonzalez Hernandez T, Castro Fuentes R, Sabate M, Garcia Dopico J. 2005. Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra. Glia 49:134-42

Sofroniew MV, Vinters HV. 2010. Astrocytes: biology and pathology. Acta Neuropathol 119:7-35

Swanson RA, Ying W, Kauppinen TM. 2004. Astrocyte influences on ischemic neuronal death. Curr Mol Med 4:193-205

Teismann P, Schulz JB. 2004. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res 318:149-6

Vesce S, Rossi D, Brambilla L, Volterra A. 2007. Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. Int Rev Neurobiol 82:57-71

Xu J, Peng H, Kang N, Zhao Z, Lin JH, Stanton PK, Kang J. 2007. Glutamate-induced exocytosis of glutamate from astrocytes. J Biol Chem 282:24185-97
Andre VM, Cepeda C, Levine MS. 2010. Dopamine and glutamate in Huntington's disease: A balancing act. CNS Neurosci Ther 16:163-78

Halliday GM, Stevens CH. 2011. Glia: initiators and progressors of pathology in Parkinson's disease. Mov Disord 26:6-17

Hazell AS. 2007. Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies. Neurochem Int 50:941-53

Matute C, Domercq M, Sanchez-Gomez MV. 2006. Glutamate-mediated glial injury: mechanisms and clinical importance. Glia 53:212-24

McGeer PL, McGeer EG. 2008. Glial reactions in Parkinson's disease. Mov Disord 23:474-83

Morales I, Fuentes A, Gonzalez-Hernandez T, Rodriguez M. 2009. Osmosensitive response of glutamate in the substantia nigra. Exp Neurol 220:335-40

Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G. 2010. Missing pieces in the Parkinson's disease puzzle. Nat Med 16:653-61

Rappold PM, Tieu K. 2010. Astrocytes and therapeutics for Parkinson's disease. Neurotherapeutics 7:413-23

Rodriguez Diaz M, Alonso TJ, Perdomo Diaz J, Gonzalez Hernandez T, Castro Fuentes R, Sabate M, Garcia Dopico J. 2005. Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra. Glia 49:134-42

Sofroniew MV, Vinters HV. 2010. Astrocytes: biology and pathology. Acta Neuropathol 119:7-35

Swanson RA, Ying W, Kauppinen TM. 2004. Astrocyte influences on ischemic neuronal death. Curr Mol Med 4:193-205

Teismann P, Schulz JB. 2004. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res 318:149-6

Vesce S, Rossi D, Brambilla L, Volterra A. 2007. Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. Int Rev Neurobiol 82:57-71

Xu J, Peng H, Kang N, Zhao Z, Lin JH, Stanton PK, Kang J. 2007. Glutamate-induced exocytosis of glutamate from astrocytes. J Biol Chem 282:24185-97

Otros artículos de Ingrid Morales

Castro R., Abreu P., Calzadilla CH and Rodriguez M. (1985) Increased or decreased locomotor response in rats following repeated administration of apomorphine depends on dosage interval. Psychopharmacology 85: 333-339.

Rodríguez M. and González-Hernandez T. (1999) Electrophysiological and morphological evidence for a GABAergic nigrostriatal pathway. Journal of Neuroscience 19: 4682-4694.

Gonzalez-Hernandez T y Rodríguez M (2000) Compartimental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. J. Comp. Neurol. 421: 107-135

Rodríguez-Oroz MC, Rodríguez M., Guridi J, Mewes K, Chockkman V, Vitek J, DeLong MR y Obeso JA (2001) The subthalamic nucleus in Parkinson´s disease: somatotopic organization and physiological characteristics. Brain 124: 1777-1790

Rodríguez M, Muñiz R, González B y Sabaté M (2004) Hand movement distribution in the motor cortex: the influence of a concurrent task and motor imagery. Neuroimage 22: 1480-1491

Rodriguez M, Jorge T, Perdomo J, Gonzalez-Hernández T, Castro R, Sabate M and Garcia-Dopico J (2004) Glial regulation of non-synaptic extracellular glutamate in the substantia nigra. Glia 49: 134-142

Rodríguez M, Alvarez-Erviti L, Javier Blesa F, Rodríguez-Oroz C, Arina A, Melero I, Isaac Ramos L, Obeso JA (2007) Mone-marrow-derived cell differentiation into microglia: A study in a progressive mouse model of Parkinson’s disease. Neurobiology of Disease 28: 316-325

Jose A Obeso, Maria C Rodriguez-Oroz, Christopher G Goetz, Concepcion Marin, Jeffrey H Kordower, Manuel Rodriguez, Etienne C Hirsch, Matthew Farrer, Anthony H V Schapira & Glenda Halliday (2010) Missing pieces in the Parkinson's disease puzzle. Nature Medicine 16: 653–661

Peter Redgrave, Manuel Rodríguez, Yoland Smith, Maria C. Rodríguez-Oroz, Stephane Lehericy, Hagai Bergman, Yves Agind, mahlon R. Delong and Jose A. Obeso (2010) Goal-directed and habitual control in the basal ganglia: implications for Parkinson’s disease. Nature Review. Neuroscience 11: 760-772

Ingrid Morales, Catalina Yanos, Clara Rodriguez-Sabate, Alberto Sanchez and Manuel Rodriguez (2013) Striatal glutamate degenerates thalamo-striatal neurons. Journal of Neuropathology and Experimental Neurology 72: 286-297. dx.doi.org/10.1097/NEN.0b013e31828a80ee.

Catalina Llanos, Manuel Rodriguez, Clara Rodriguez-Sabate, Ingrid Morales and Magdalena Sabate (2013) Mu-rhythm changes during the planning of motor and motor imagery actions. Neuropsychologia 51: 1019-1026

Clara Rodriguez-Sabate, Catalina Llanos, Ingrid Morales, Roberto Garcia-Alvarez, Magdalena Sabate and Manuel Rodriguez (2015) The functional connectivity of intralaminar thalamic nuclei in the human basal ganglia. Human Brain Mapping 36: 1335-1347. 10.1002/hbm.22705

Rodriguez M, Rodriguez-Sabate C, Morales I, Sanchez A, Sabate M (2015) Parkinson’s disease as a result of aging. Aging Cell 14: 293-308 Doi: 10.1111/acel.12312.

Para comunicarse con Ingrid Morales mencionar a SIIC como referencia:
Inmope@hotmail.com

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Acerca del trabajo completo

EL ESTRIADO EN EL ORIGEN Y LA PROGRESIÓN DE LA ENFERMEDAD DE PARKINSON.

Título original en castellano
ACUMULACION AUTOINDUCIDA DE GLUTAMATO EN ASTROCITOS Y EXCITOTOXICIDAD EN LOS GANGLIOS BASES.

Autores
Ingrid Morales¹, Ingrid Morales²
1 Biología, Departamento de Fisiología, Facultad de Medicina, Universidad de la Laguna, la Laguna, Tenerife, Islas Canarias, España Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (ciberned), Investigador Contratado
2 Biologa, Ciberned

Acceso a la fuente original
Glia
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-1136/homepage/ProductInformation.html

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