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EL PAPEL DEL FACTOR DE CRECIMIENTO DEL ENDOTELIO VASCULAR EN LA ANGIOGENESIS

(especial para SIIC © Derechos reservados)
Dado que la angiogénesis es un acontecimiento clave en el crecimiento tumoral, invasión y metástasis, se ha propuesto al factor de crecimiento del endotelio vascular como blanco terapéutico en varios tipos de tumores.
Autor:
Nicola Maruotti
Columnista Experto de SIIC

Institución:
University of Foggia Medical School

Artículos publicados por Nicola Maruotti
Coautor
Domenico Ribatti* 
University of Bari Medical School, Bari, Italia*
Recepción del artículo
2 de Mayo, 2007 		Aprobación
17 de Septiembre, 2007
Primera edición
10 de Abril, 2008 		Segunda edición, ampliada y corregida
7 de Junio, 2021

EL PAPEL DEL FACTOR DE CRECIMIENTO DEL ENDOTELIO VASCULAR EN LA ANGIOGENESIS

Resumen
El factor de crecimiento del endotelio vascular (VEGF) es un factor angiogénico importante. La familia de los VEGF incluye VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E y el factor de crecimiento placentario (PlGF), los cuales, mediante diferentes interacciones con tres receptores de tirosina quinasa, que incluyen VEGFR-1/Flt-1, VEGFR-2/Flk-1 y VEGFR-3/Flt-4 y dos receptores de tirosina quinasa no proteicos, incluidos neuropilina 1 y neuropilina 2, son responsables de la proliferación de células endoteliales, migración y expresión de quimioquinas, citoquinas y metaloproteinasas de la matriz. Se ha detectado VEGF, que se expresa en respuesta a citoquinas, factores de crecimiento, hormonas, proteasas extracelulares e hipoxia, en diferentes tejidos como encéfalo, hígado, bazo, riñón y piel, donde es producido por varios citotipos, que incluyen células endoteliales, fibroblastos, queratinocitos, macrófagos, mastocitos y células tumorales. El VEGF participa en varias condiciones fisiológicas y patológicas, que incluyen desarrollo del embrión, vasculogénesis y hematopoyesis temprana, ovulación, reparación de heridas, psoriasis, endometriosis, aterosclerosis, retinopatía diabética, degeneración macular neovascular del ojo relacionada con la edad, enfermedades inflamatorias crónicas y tumores. Dado que la angiogénesis es un acontecimiento clave en el crecimiento tumoral, invasión y metástasis, se ha propuesto al VEGF como blanco terapéutico de varios tipos tumorales, como cáncer de mama, de células renales, colorrectal y de pulmón de células no pequeñas. Además, el VEGF puede ser un agente terapéutico interesante en las enfermedades cardíacas y periféricas isquémicas.

Palabras clave
angiogénesis, antiangiogénesis, célula endotelial, crecimiento tumoral


Artículo completo
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Extensión:  +/-10.73 páginas impresas en papel A4
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The role of vascular endothelial growth factor in angiogenesis

Abstract
Vascular endothelial growth factor (VEGF) is an important angiogenic factor. VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E and placental growth factor (PlGF) which by different interactions with three tyrosine kinase receptors, including VEGFR-1/Flt-1, VEGFR-2/Flk-1 and VEGFR-3/Flt-4, and two non protein tyrosine kinase receptors, including neuropilin-1 and -2, are responsible for endothelial cells proliferation, migration and expression of chemokines, cytokines and matrix metalloproteinases. VEGF, expressed in response to cytokines, growth factors, hormones, extracellular proteases, and hypoxia, has been detected in different tissues, such as brain, liver, spleen, kidney and skin, where it is produced by several cytotypes, including endothelial cells, fibroblasts, keratinocytes, macrophages, mast cells and tumor cells. VEGF is involved in several physiological and pathological conditions, including embryo development, vasculogenesis and early hematopoiesis, ovulation, wound repair, psoriasis, endometriosis, arteriosclerosis, diabetic retinophathy, neovascular age-related macular degeneration of the eye, chronic inflammatory diseases, and tumors. Since angiogenesis is a key event in tumor growth, invasion and metastasis, VEGF has been proposed as a therapeutic target in several tumor types, such as breast cancer, renal cell cancer, colorectal cancer and non small cells lung cancer. Furthermore, VEGF may be an interesting therapeutic agent in ischemic heart and peripheral diseases.

Key words
angiogenesis, antiangiogenesis, endothelial cell, tumor growth


Full text
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Especialidades
Principal: Bioquímica, Oncología
Relacionadas: Cardiología, Farmacología, Inmunología, Medicina Interna



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Enviar correspondencia a:
Domenico Ribatti, University of Bari Medical School Department of Human Anatomy and Histology, I-70124, Piazza Giulio Cesare, 11, Bari, Italia
Patrocinio y reconocimiento:
Financiado por la Associazione Italiana per la Ricerca sul Cancro (AIRC, National and Regional Funds) Milán, Ministerio de Educación, Universidades e Investigación (Proyecto CARSO n. 72/2; FIRB 2001 and PRIN 2005), Roma, y Fondazione Italiana per la Lotta al Neuroblastoma, Génova, Italia.
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