HEMORRAGIA SUPRATENTORIAL ESPONTANEA: UN MODELO MATEMATICO PREDICTIVO DE MORTALIDAD

(especial para SIIC © Derechos reservados)
Estudio prospectivo realizado en las Unidades de Terapia Intensiva del Hospital General Manuel Belgrano y del Policlínico Central de la Unión Obrera Metalúrgica, Buenos Aires, Argentina.
Autor:
Fernando Racca velásquez
Columnista Experta de SIIC

Institución:
Hospital Zonal de Agudos General Manuel Belgrano


Artículos publicados por Fernando Racca velásquez
Coautores
Adolfo Eduardo Alsina* Fernando Racca Velásquez* 
Médico, Hospital Zonal de Agudos General Manuel Belgrano, San Martín, Argentina*
Recepción del artículo
10 de Enero, 2014
Aprobación
25 de Febrero, 2014
Primera edición
20 de Marzo, 2014
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
Objetivo: Plantear un modelo matemático predictivo de mortalidad para la hemorragia supratentorial espontánea. Material y métodos: Se efectuó un estudio prospectivo en las unidades de Terapia Intensiva del Hospital General Manuel Belgrano y el Policlínico Central de la Unión Obrera Metalúrgica (Buenos Aires, Argentina). Se evaluó la localización de la hemorragia, el volumen del hematoma (V), la presencia de volcado ventricular (VV) y la desviación de la línea media (DLM). Resultados: El análisis mostró que el volumen del hematoma, la desviación de la línea media y la presencia de volcado ventricular se comportaron como factores predictivos independientes de mortalidad. Por el método de regresión logística múltiple se demuestra que el volcado ventricular incrementa el riesgo de mortalidad en 3.1 veces. Por cada centímetro cúbico de aumento del volumen del hematoma se incrementa la mortalidad un 6.2%, y por cada milímetro de desviación de la línea media la probabilidad de mortalidad se incrementa en 32.8%. Este modelo demuestra tener una sensibilidad del 79.8% y una especificidad del 95.2%. El rango de clasificación correcta es del 89%. El logit del modelo fue: -4.948 + 1.415 (VV) + 0.06 (V) + 0.248 (DLM). Conclusiones: En la población en estudio fue posible plantear un modelo matemático de probabilidad con alta sensibilidad y especificidad.

Palabras clave
hemorragia intracerebral, hemorragia supratentorial, pronóstico, modelo estadístico, tomografía computarizada


Artículo completo

(castellano)
Extensión:  +/-5.45 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

Abstract
Background: The aim of this study was to assess the predictive value of a CT scan score in spontaneous supratentorial hemorrhage. Materials and methods: A prospective study took place in intensive care units at the General Belgrano Hospital and at the Central Clinic of the Metal Workers Trade Union (Buenos Aires, Argentina). The location of the hemorrhage, the volume of the hematoma (HV), the midline shift (MLS) and the presence of intraventricular hemorrhage (IVH) were evaluated. Results: By using multiple logistic regression analysis in a mathematical mortality probability model, hematoma volume, midline shift and intraventricular hemorrhage behaved as independent predictive factors of mortality. Each ml increase in hematoma volume increases mortality by 6.2%. Intraventricular hemorrhage shows a threefold increase in mortality, and for every mm of midline shift the probability rises by 32.8%. The model showed a sensibility of 79.8% and a specificity of 95.2%. Model logit was as follows: -4.948 + 1.415 (IVH) + 0.06 (V) + 0.248 (MLS). Conclusion: In the study population it was possible to apply a mathematical model of probability with high specificity and sensibility.

Key words
intracerebral hemorrhage, supratentorial hemorrhage, prognosis, statistical model, computed tomography


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Cuidados Intensivos, Neurocirugía
Relacionadas: Diagnóstico por Imágenes, Emergentología, Informática Biomédica, Neurología



Comprar este artículo
Extensión: 5.45 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Enviar correspondencia a:
Fernando Racca Velásquez, 1406, Jose Bonifacio 1748 6º "A", Ciudad Autónoma de Buenos Aire, Argentina
Bibliografía del artículo
1. Kunitz SC, Gross CR, Heyman CS, Mohr JP, Price TR, Wolf PA. The pilot Stroke Data Bank: definition, design and data. Stroke 15:740-746, 1984.
2. Gross CR, Kase CS, Mohr JP, Cunningham SC, Baker WE. Stroke in south Alabama: incidence and diagnostic features: a population-based stuffy. Stroke 15:249-255, 1984.
3. Bamford J, Sandercock T, Dennis M, Burn J, Warlow C. A prospective stuffy of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project 1981 - 1986, II: incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 53:16-22, 1990.
4. Qureshi A, Tuhrim S, Broderick J, Batjer H, Hondo H, Hanley D. Spontaneous intracerebral hemorrhage. N Eng J Med 344:1450-1460, 2001.
5. Elijovich L, Patel PV, Hemphill JC 3ed. Intracerebral hemorrhage. Semin Neurol 28(5):657-67, 2008.
6. Badjatia N, Rosand J. Intracerebral hemorrhage. Neurologist 11(6):311-24, 2005.
7. Dennis MS, Burn JP, Sandercock PA, Bamford JM, Wade DT, Warlow CP. Long-term survival after first-ever stroke: the Oxfordshire Community Stroke Project. Stroke 24:796-800, 1993.
8. Sacco RL, Mayer SA. Epidemiology of intracerebral hemorrhage. In: Feldman E, ed. Intracerebral hemorrhage. Armonk, N.Y., Futura Publishing pp. 3-23, 1994.
9. Tetri S, Juvela S, Saloheimo P, Pyhtinem J, Hillbom M. Hypertension and diabetes as predictors of early death after spontaneous intracerebral hemorrhage. J Neurosurg 110:411-7, 2009.
10. Daverat P, Castel JP, Dartigues JF, Orgogozo JM. Death and functional outcome after spontaneous intracerebral hemorrhage: a prospective study of 166 cases using multivariate analysis. Stroke 221:1-6, 1991.
11. Franke CL, Van Sweiten JC, Algra A, Van Gijn J. Prognostic factors in patients with intracerebral haematoma. J Neurol Neurosurg Psychiatry 55:653-657, 1992.
12. Lisk DR, Pasteur W, Rhoades H, Putnam RD, Grotta JC. Early presentation of hemispheric intracerebral hemorrhage: prediction of outcome and guidelines for treatment allocation. Neurology 44:133-139, 1994.
13. Hemphill JC, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke 32:894-897, 2001.
14. Ariesen MJ, Algra A, Van der Worp HB, Rinkel GJE. Applicability and relevance of models that prediction short term outcome after intracerebral haemorrhage. J Neurol Neurosurg Psychiatry 76:839-44, 2005.
15. Godoy DA, Piñero G, Di Napoli M. Predicting mortality in spontaneous intracerebral hemorrhage, can modification to original score improve the prediction? Stroke 37:1038, 2006.
16. Clarke JL, Johnston SC, Farrant M, Bernstein R, Tong D. Hemphill JC 3rd External validation of the ICH score. Neurocrit Care 1(1):53-60, 2004.
17. Barbieri A, Pinna C, Basso GP, Molinari R, Giuliani E, Fruggeri L, Nolli M. Specifity and reability of prognostic indexes in intensive care evaluation: The spontaneous cerebral haemorrhage case. J Eval Clin Pract 15:242-5, 2009.
18. Cheung RT, Zou LY. Use of the original, modified, or new intracerebral hemorrhage score to predict mortality and morbidity after intracerebral hemorrhage. Stroke 34:1717-1722, 2003.
19. Garibi J, Bilbao G, Pomposo I, Hostalot C. Prognostic factors in a series of 185 consecutive spontaneous supratentorial intracerebral haematomas. Br J Neurosurg 16:355-361, 2002.
20. Karnik R, Valentin A, Ammerer HP, Hochfelner A, Donath P, Slany J. Outcome in patients with intracerebral hemorrhage: predictor of survival. Wien Klin Wochenschr 112(4):169-173, 2000.
21. Broderick JP, Brott TG, Duldner JE, Tomsick T, Huster G. Volume of intracerebral hemorrhage. A powerful and easy-to use predictor of 30 day mortality. Stroke 24:987-993, 1993.
22. Kim KH. Predictors of 30 day mortality and 90 day functional recovery after primary intracerebral hemorrhage: hospital based multivariate analysis in 585 patients. J Korean Neurosurg Soc 45:341-9, 2009.
23. Ruiz-Sandoval JL, Chiquete E, Romero-Vargas S, Padilla-Martinez JJ, Gonzalez-Cornejo S. Grading scale for outcome in primary intracerebral hemorrhages. Stroke 38(11):133-5, 2007.
24. Lahoz CH, Mateos V, Salas-Puig X, Tunon A, Guisasola LM. Prognosis of supratentorial parenchymal hemorrhages. Neurología 9(7):269-276, 1994.
25. Thurin S, Horowitz DR, Sacher M, Godbold JH. Validation and comparison of models predicting survival following intracerebral hemorrhage. Crit Care Med 23(5):950-4, 1995.
26. Lampl Y, Gilad R, Eshel Y, Sarova-Pinhas I. Neurogical and Functional Outcome in Patients with Supratentorial Hemorrhages. Stroke 26:2249-53, 1995.
27. Tuhrim S. Intracerebral hemorrhage - Improving outcome by reducing volume? N Eng J Med 358:2174-2176, 2008.
28. Nilsson OG, Lindgren A, Brandt L, Saveland H. Prediction of death in patients with primary intracerebral hemorrhage: a prospective study of a defined population. J Neurosurg 97(3):531-6, 2002.
29. Yoshioka S. Wada H, Matsukado Y. Prognostic significance of intraventricular hematoma in the cases of intracraneal hemorrhage. No Shinkei Geka 12:709-15, 1984.
30. Verma A, Maheshwari MC, Bhargava S. Spontaneous intraventricular haemorrhage. J Neurol 233-6, 1987.
31. Diamond P, Gale S, Stewart K. Primary intracerebral haemorrhage clinical and radiologic predictors of survival and functional outcome. Disabil Rehabil 25:689-98, 2003.
32. Young WB, Lee KP, Pessin MS, Kwan ES, Rand WM, Caplan LR. Prognostic significance of ventricular blood in supratentorial hemorrhage: a volumetric study. Neurology 40(4):616-9, 1990.
33. Tuhrim S, Horowitz DR, Sacher M, Godbold JH. Volume of ventricular blood is an important determinant of outcome in supratentorial intracerebral hemorrhage. Crit Care Med 617-21, 1999.
34. Bhattathiri PS, Gregson B, et al. Intraventricular hemorrhage and hydrocephalus after spontaneous intracerebral hemorrhage: results from the STICH trial. Acta Neurochir Suppl 65-8, 2006.
35. Bhattathiri PS, Gregson B, Prasad KS, Mendelow AD; STICH Investigators. Intraventricular hemorrhage and hydrocephalus after spontaneous intracerebral hemorrhage:results from the STICH trial. Acta Neurochir Suppl 96:65-8, 2006.
36. Castellanos M, Leira R, Tejada J, Gil-Peralta A, Dávalos A, Castillo J; Stroke Project, Cerebrovascular Diseases Group of the Spanish Neurological Society. Predictors of good outcome in medium to large spontaneous supratentorial intracerebral haemorrhages. J Neuro Neurosur Psychiatry 76(5):691-5, 2005.
37. Hallevi H, Albright KC, Aronowski J, Barreto AD, Martin-Schild S, Khaja AM, Gonzales N, Illoh K, Noser EA, Grotta JC. Intraventricular hemorrhage Anatomic relationships and clinical implication. Neurology 70:848-52, 2008.
38. Hanley DF. Intraventricular hemorrhage: severity factor and treatment target in spontaneous intracerebral haemorrhage. Stroke 40(4):1533-38, 2009.
39. Chavero Magro MJ, Rivera Fernández R, Busquier Hernández H, Fernández Mondéjar E, Pino Sánchez F, Díaz Contreras R, et al. Med Intensiva 31:281-8, 2007.
40. Hallevy C, Ifergane G, Kordysh E, Herishanu Y. Spontaneous supratentorial intracerebral hemorrhage. Criterial for short-term functional outcome prediction. J Neurol 249:1704-1709, 2002.

 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618
Inicio/Home

Copyright siicsalud © 1997-2024 ISSN siicsalud: 1667-9008