Amelia Marti Del Moral *

Autora invitada por SIIC

Recibió el Premio de la Sociedad Británica de Nutrición 2007

LOS GENES Y EL ESTILO DE VIDA CAUSAN LA OBESIDAD

Mutaciones en genes relacionados con la regulación del apetito y de la adiposidad principalmente interactúan con factores del estilo de vida (dieta, actividad física) aumentando el riesgo de obesidad.

*Amelia Marti Del Moral
describe para SIIC los aspectos relevantes de su trabajo
INTERACTION BETWEEN GENES AND LIFESTYLE FACTORS ON OBESITY
Institución principal de la investigación
*Universidad de Navarra, Pamplona, España
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Otros artículos escogidos

Referencias bibliográficas
Moreno-Aliaga MJ, Marti A, García-Foncillas J, Martínez JA. DNA Hybridization Arrays: a powerful technology for obesity research. Br J Nutr 86, 119-122, 2001.
Martínez JA, Enriquez L, Moreno-Aliaga MJ, Marti A. Genetics of obesity. Public Heath Nutrition (In press), 2007.
Marti A, Martínez JA. Genetics of obesity: gene x diet interaction. Int J Vitam Nutr Res 76:1-10, 2006.
Ochoa MC, Santos JL, Azcona C, Moreno-Aliaga MJ, Martínez-González MA, Martínez JA, Marti A and GENOI. Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. Mol Gen Metab (In press), 2007.
Marti A, De Miguel C, Jebb SA, Lafontan M, Laville M, Palou A, Remesar X, Trayhurn P, Martínez JA. Methodological approaches to assess body-weight regulation and aetiology of obesity. Proc Nutr Soc 59:405-411, 2000.
Marti A, Novo FJ, Martínez-Anso E, Zaratiegui M, Aguado M, Martínez JA. Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice. Biochem Biophys Res Commun 246:859-862, 1998.
Marti A, Berraondo B, Martínez JA. Leptin: physiological actions. J Physiol Biochem 55:43-50, 1999.
Fischer-Posovszky P, Wabitsch M, Hochberg Z. Endocrinology of adipose tissue - an update. Horm Metab Res 39:314-321, 2007.
Walley AJ, Blakemore AI, Froguel P. Genetics of obesity and the prediction of risk for health. Hum Mol Genet 15(2):R124-130, 2006.
Marti A, Corbalán MC, Forga L, Martínez JA, Hinney A, Hebebrand J. A novel nonsense mutation in the the melanocortin-4 receptor associated with obesity in a Spanish population. Int J Obes Relat Metab Disord 27:385-388, 2003.
Ochoa MC, Azcona C, Biebermann H, Brumm H, Razquin C, Wermter AK, Martínez JA, Hebebrand J, Hinney A, Moreno-Aliaga MJ, Marti A & GENOI members. A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescents population. Clin Endocrinol 66:652-658, 2007.
Higgins SC, Gueorguiev M, Korbonits M. Ghrelin, the peripheral hunger hormone. Ann Med 39:116-136, 2007.
Ochoa MC, Marti A, Martinez JA. Obesity studies in candidate genes. Med Clin (Barc) 122:542-551, 2004.
Macho-Azcárate T, Calabuig J, Marti A. Martínez JA. A maximal effort trial in Gln27Glu polymorphism genotyped obese women. J Physiol Biochem 58:103-108, 2002.
Macho-Azcárate T, Marti A, Martínez JA, Ibañez J. The Gln27Glu polymorphism outcome in obese women submitted to a maximal effort trial. Int J Obes Relat Metab Disord 26:1434-1441, 2002.
Macho-Azcárate T, Marti A, Calabuig, Martínez JA. Basal fat oxidation and after a peak oxygen consumption test in obese women with a beta 2-adrenoceptor gene polymorphism. J Nutr Biochem 14:275-279, 2003.
Corbalán MS, Marti A, Forga L, Martínez-González MA, Martínez JA. Beta2-adrenoceptor polymorphism and abdominal obesity risk: effect modification by gender and HDL-cholesterol levels. Eur J Nutr 41:114-118, 2002.
Corbalán MS, Marti A, Forga L, Martínez-González MA, Martínez JA. The obesity risk and the Trp64Arg polymorphism of the beta3-adrenoceptor gene: effect modification by age. Ann Nutr Metab 46:152-158, 2002.
Corbalán MS, Margareto J, Martínez JA, Marti A. High fat feeding reduced muscle uncoupling protein 3 expression in rats. J Physiol Biochem 55:67-73, 1999.
Marti A, Larrarte E, Novo FJ, García M, Warden CH, Martínez JA. UCP2 muscle gene transfer modifies mitochondrial membrane potential. Int J Obes Relat Metab Disord 25:68-75, 2001.
Larrarte E, Novo FJ, Marti A, Martínez JA. UCP1 muscle gene transfer and mitochondrial proton leak mediated thermogenesis. Arch Biophys Biochem 404:166-171, 2002.
Marti A, Vaquerizo J, Zulet MA, Moreno-Aliaga MJ, Martínez JA. Down-regulation of heart H-FABP and UCP2 gene expressions in diet-induced (cafeteria) obese rats. J Physiol Biochem 58:69-74, 2002.
Marti A, Corbalán MS, Forga L, Martínez-González MA, Martínez JA. Higher obesity risk associated with the exon 8 insertion allele of the UCP2 gene in a Spanish case-control study. Nutrition 20:498-501, 2004.
Alonso A, Martí A, Corbalán MS, Martínez-González MA, Martínez JA. Association of UCP3 gene -55C>T polymorphism and obesity in a Spanish population: a case-control study. Ann Nutr Metab 49:183-188, 2005.
Margareto J, Marti A, Martínez JA. Changes in UCP mRNA expression levels in brown adipose tissue and skeletal muscle after feeding a high-energy diet and relationships with leptin, glucose and PPARG2. J Nutr Biochem 12:130-137, 2001.
López I, Marti A, Milagro F, Zulet MA, Moreno-Aliaga MJ, Martínez JA. DNA microarray analysis of gene differentially expressed in diet-induced obese rats. Obes Res 11:188-194, 2003.
Ochoa MC, Marti A, Azcona C, Chueca M, Oyarzábal M, Pelach R, Patiño A, Moreno-Aliaga MJ, Martínez-González MA, Martínez JA. Gene-gene interaction between PPARgamma2 and ADRbeta3 increases obesity risk in children and adolescents. Int J Obes Relat Metab Disord 28:S37-41, 2004.
Marti A, Corbalán, MS, Martínez-González MA, Forga L, Martínez JA. CHO intake alters obesity risk associated with Pro12Ala polymorphism of PPARG gene. J Physiol Biochem 58:219-220, 2002.
Ochoa MC, Moreno-Aliaga MJ, Martinez-Gonzalez MA, Martinez JA, Marti A, GENOI Members. Predictor factors for childhood obesity in a Spanish case-control study. Nutrition 23:379-384, 2007.
Marti A, Moreno-Aliaga MJ, Hebebrand J, Martínez JA. Genes, lifestyles and obesity. Int J Obes Relat Metab Disord 28:S29-36, 2004.
Martínez JA, Corbalán, MS, Sánchez Villegas A, Forga, L, Marti A, Martínez-González MA. Obesity risk is asociated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism. J Nutr 133:2549-2554, 2003.
Marti A, Corbalán MC, Martínez-González MA, Martínez JA. Trp64Arg polymorphism of the beta3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes Obes Metab 4:428-430, 2002.
Corbalán MS, Marti A, Forga L, Martínez-González MA, Martínez JA. The 27Glu polymorphism of the beta2-adrenergic receptor interacts with physical activity influencing obesity risk among female subjects. Clin Genet 61:305-307, 2002.
Ochoa MC, Moreno-Aliaga MJ, Martínez-González MA, Martínez JA, GENOI members, Marti A. TV watching modifies obesity risk linked to the Gln27Glu polymorphism of ADRB2 gene in girls. Int J Ped Obes 1:83-88, 2006.

Otros artículos de Amelia Marti Del Moral

1. Martinez JA, Parra MD, Santos JL, Moreno-Aliaga MJ, MARTI A, Martinez-Gonzalez MA.Genotype-dependent response to energy-restricted diets in obese subjects: towards personalized nutrition.Asia Pac J Clin Nutr. 2008;17 Suppl 1:119-22.
2. MARTI A, Martinez-González MA, Martinez JA.Interaction between genes and lifestyle factors on obesity.Proc Nutr Soc. 2008 Feb;67(1):1-8.
3. Martínez-Hernández A, Enríquez L, Moreno-Moreno MJ, MARTI A.Genetics of obesity.Public Health Nutr. 2007 Oct;10(10A):1138-44.
4. Zulet MA, Puchau B, Navarro C, MARTI A, Martínez JA.[Inflammatory biomarkers: the link between obesity and associated pathologies]Nutr Hosp. 2007 Sep-Oct;22(5):511-27.
5. Ochoa MC, Moreno-Aliaga MJ, Martínez-González MA, Martínez JA, MARTI A; GENOI Members.TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls.Int J Pediatr Obes. 2006;1(2):83-8.
6. Ochoa MC, Santos JL, Azcona C, Moreno-Aliaga MJ, Martínez-González MA, Martínez JA, MARTI A; GENOI Members.Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents.Mol Genet Metab. 2007 Dec;92(4):351-8.
7. Pérez-Matute P, Martínez JA, MARTI A, Moreno-Aliaga MJ.Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin.Lipids. 2007 Oct;42(10):913-20.
8. Ochoa MC, Azcona C, Biebermann H, Brumm H, Razquin C, Wermter AK, Martínez JA, Hebebrand J, Hinney A, Moreno-Aliaga MJ, MARTI A, Patiño A, Chueca M, Oyarzabal M, Pelach R; Grupo de Estudio Navarro de la Obesidad Infantil (GENOI).A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population.Clin Endocrinol (Oxf). 2007 May;66(5):652-8.
9. Ochoa MC, Moreno-Aliaga MJ, Martínez-González MA, Martínez JA, MARTI A; GENOI Members.Predictor factors for childhood obesity in a Spanish case-control study.Nutrition. 2007 May;23(5):379-84.
10. Pérez-Matute P, MARTI A, Martínez JA, Fernández-Otero MP, Stanhope KL, Havel PJ, Moreno-Aliaga MJ.Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes.Mol Cell Endocrinol. 2007 Mar 30;268(1-2):50-8.
11. Pérez-Matute P, Pérez-Echarri N, Martínez JA, MARTI A, Moreno-Aliaga MJ.Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha.Br J Nutr. 2007 Feb;97(2):389-98.
12. MARTI A, Martinez JA.Genetics of obesity: gene x nutrient interactions.Int J Vitam Nutr Res. 2006 Jul;76(4):184-93.
13. Lorente-Cebrián S, Pérez-Matute P, Martínez JA, MARTI A, Moreno-Aliaga MJ.Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes.J Physiol Biochem. 2006 Jun;62(2):61-9.
14. MARTI A, Ochoa MC, Sánchez-Villegas A, Martínez JA, Martínez-González MA, Hebebrand J, Hinney A, Vedder H.Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity.BMC Med Genet. 2006 May 25;7:50.

Para comunicarse con Amelia Marti Del Moral mencionar a SIIC como referencia:
amarti@unav.es

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Acerca del trabajo completo

LOS GENES Y EL ESTILO DE VIDA CAUSAN LA OBESIDAD

Título original en castellano
INTEACCIONES ENTRE VARIANTES GENETICAS Y EL ESTILO DE VIDA EN EL DESARROLLO DE LA OBESIDAD

Autor
Amelia Marti Del Moral¹
1 Profesor Titular, Universidad de Navarra, Pamplona, España, Vicedecana

Acceso a la fuente original
Proceedings of the Nutrition Society
http://journals.cambridge.org/action/displayJournal?jid=PNS

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