Isabel Azevedo *

Autor invitado por SIIC

Uso de conceitos e métodos físico-matemáticos para mostrar que quanto maiores são os adipócitos mais fácil é que morram por rotura

QUANTO MAIOR O TAMANHO DOS ADIPÓCITOS, MAIS PROVÁVEL A SUA MORTE POR ROTURA

O tamanho excessivo dos adipócitos facilita a sua rotura. Esta rotura, previsivelmente mais frequente nos adipócitos intra-abdominais, sujeitos a apreciáveis variações de pressão, está na base da chamada de macrófagos e outras manifestações de inflamação. A prevenção da hipertrofia dos adipócitos deverá acompanhar-se duma redução significativa da morbilidade associada à obesidade.

*Isabel Azevedo
describe para SIIC los aspectos relevantes de su trabajo
ADIPOCYTE SIZE AND LIABILITY TO CELL DEATH
Institución principal de la investigación
*Serviço de Bioquímica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
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Referencias bibliográficas
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Otros artículos de Isabel Azevedo

Negrão MR, Keating E, Faria A, Azevedo I, Martins MJ. Acute effect of tea, wine, beer, and polyphenols on ecto-alkaline phosphatase activity in human vascular smooth muscle cells. J Agric Food Chem 2006; 54:4982-4988.
Negrão MR, Mota A, Azevedo I, Martins MJ. Statins and tissue mineralization: putative involvement of alkaline phosphatase. Med Hypotheses 2006; 67:524-528.
Ribeiro L, Martel F, Azevedo I. The release of 3H-1-methyl-4-phenylpyridinium from bovine adrenal chromaffin cells is modulated by somatostatin. Reg Peptides 2006, in press.
Monteiro R, Azevedo I, Calhau C. Modulation of aromatase activity by diet polyphenolic compounds. J Agric Food Chem 2006; 54:3535-3540.
Monteiro R, Calhau C, Martel F, Faria A, Mateus N, Azevedo I. Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells. Naunyn-Schmiedeberg's Arch Pharmacol 372:147-152, 2005.
Martel F, Keating E, Calhau C, Grundemann D, Schomig E, Azevedo I. Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracelular second messenger systems. Naunyn-Schmiedeberg's Arch Pharmacol 364:487-95, 2001.
Martel F, Keating E, Azevedo I. Effect of P-glycoproteinamodulators on the human extraneuronal monoamine transporter. Eur J Pharmacol 422:31-37, 2001.
Martel F, Ribeiro L, Calhau C, Azevedo I. Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn-Schmiedeberg's Arch Pharmacol 359:303-309, 1999.
Martel F, Martins MJ, Hipólito-Reis C, Azevedo I. Inward transport of [3H]-1-methyl-4-phenylpyridinium in rat isolated hepatocytes: putative involvement of a P-glycoprotein transporter. Br J Pharmacol 119:1519-1524, 1996.
Martel L, Calhau C, Soares da Silva P, Azevedo I. Transport of [3H]MPP+ in na immortalized rat brain endothelial cell line (RBE4). Naunyn-Schmiedeberg's Arch Pharmacol 363:1-10, 2001.

Para comunicarse con Isabel Azevedo mencionar a SIIC como referencia:
isabelaz@med.up.pt

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Acerca del trabajo completo

QUANTO MAIOR O TAMANHO DOS ADIPÓCITOS, MAIS PROVÁVEL A SUA MORTE POR ROTURA



Autores
Isabel Azevedo¹, Rosário Monteiro², Paulo M S T de Castro³, Conceição Calhau⁴
1, Serviço de Bioquímica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
2, Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Assistente
3, Departamento de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Professor
4, Serviço de Bioquímica, Faculdade de Medicina, Universidade do Porto, Professora

Acceso a la fuente original
Obesity Surgery
http://www.obesitysurgery.com/

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