Enrique Hugo Luque *

Autor invitado por SIIC

La exposición a bajas dosis (aquellas consideradas “ambientalmente relevantes”) del xenoestrógeno bisfenol A en etapas tempranas del desarrollo de la hembra altera la respuesta del útero al estímulo de los esteroides ováricos.

LA EXPOSICION NEONATAL A XENOESTROGENOS ALTERA LA RESPUESTA DEL UTERO RELACIONADA CON LA IMPLANTACION

Se sugiere que la alteración de la expresión de Hoxa10 y Hoxa11 debido a la exposición neonatal a xenoestrógenos sería responsable de reprogramar la respuesta normal de las células del estroma uterino al estímulo de E y P durante la vida adulta.

*Enrique Hugo Luque
describe para SIIC los aspectos relevantes de su trabajo
DEVELOPMENTAL EXPOSURE TO BISPHENOL A IMPAIRS THE UTERINE RESPONSE TO OVARIAN STEROIDS IN THE ADULT
Institución principal de la investigación
*Universidad Nacional del Litoral, Santa Fe, Argentina
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Otros artículos de Enrique Hugo Luque

Stoker C, Beldoménico PM, Bosquiazzo VL, Zayas MA, Rey F, Rodríguez H, Muñoz de Toro M, Luque EH. Developmental exposure to endocrine disruptor chemicals alters follicular dynamics and steroid levels in Caiman latirostris. General and Comparative Endocrinology 156:603-612, 2008.
Varayoud J, Monje L, Bernhardt T, Muñoz de Toro M, Luque EH, Ramos JG. Endosulfan modulates estrogen-dependent genes like a non-uterotrophic dose of 17beta-estradiol. Reproductive Toxicology 26:138-45, 2008.
Beldoménico PM, Rey F, Prado WS, Villarreal JC, Muñoz de Toro M, Luque EH. In ovum exposure to pesticides increases the egg weight loss and decreases hatchlings weight of Caiman latirostris (Crocodylia: Alligatoridae). Ecotoxicology and Environmental Safety 68:246-251, 2007.
Durando M, Kass L, Piva J, Sonnenschein C, Soto AM, Luque EH, Muñoz de Toro M. Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats. Environmental Health Perspective 115:80-86, 2007.
Muñoz de Toro M, Durando M, Beldomenico PM, Beldomenico HR, Kass L, Garcia SR, Luque EH. Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarkers expression in ER-positive breast carcinomas. Breast Cancer Research 8:R47, 2006.
Muñoz de Toro M, Beldoménico HR, García SR, Stoker C, De Jesús JJ, Beldoménico PM, Ramos JG, Luque EH. Organochlorine levels in adipose tissue of women from a littoral region of Argentina. Environmental Research 102:107-112, 2006.
Muñoz de Toro M, Markey CM, Wadia P, Luque EH, Rubin BS, Sonnenschein C, Soto AM. Perinatal exposure to bisphenol A alters peripubertal mammary gland development in mice. Endocrinology 146:4138-4147, 2005.
Ramos JG, Varayoud J, Kass L, Costabel L, Rodríguez H, Muñoz de Toro M, Luque EH. Bisphenol A induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats. Endocrinology 144:3206-3215, 2003.
Stoker C, Rey F, Rodríguez H, Ramos JG, Sirosky p, Larriera A, Luque EH, Muñoz de Toro M. Sex reversal effects on Caiman latirostris exposed to environmental relevant doses of the xenoestrogen bisphenol A. General and Comparative Endocrinology 133:287-296, 2003.
Ramos JG, Varayoud J, Sonnenschein C, Soto AM, Muñoz de Toro M, Luque EH. Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate. Biology of Reproduction 65:1271-1277, 2001.

Para comunicarse con Enrique Hugo Luque mencionar a SIIC como referencia:
eluque@fbcb.unl.edu.ar

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LA EXPOSICION NEONATAL A XENOESTROGENOS ALTERA LA RESPUESTA DEL UTERO RELACIONADA CON LA IMPLANTACION

Título original en castellano
LA EXPOSICION A BISFENOL A DURANTE EL DESARROLLO NEONATAL ALTERA LA RESPUESTA UTERINA A LOS ESTEROIDES OVARICOS EN HEMBRAS ADULTAS

Autores
Enrique Hugo Luque¹, Jorgelina Varayoud²
1 Médico Veterinario, Laboratorio de Endocrinología y Tumores Hormonodependientes, Facultad de Bioquímica, Universidad Nacional del Litoral, Santa Fe, Argentina, Profesor Titular
2 Bioquímica, Leth, Facultad de Bioquímica y Ciencias Biológicas, Unl

Acceso a la fuente original
Endocrinology
http://endo.endojournals.org/

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