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Hua Yan describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo ELEVATED INTRAVITREAL IL-1BETA AND IL-10 LEVELS IN PDR In order to determine the roles of IL-1beta and IL-10 in the vitreous of PDR, we measured IL-1beta and IL-10 concentration by ELISA. We found vitreous levels of IL-1beta and IL-10 were upregulated in PDR patients, and these two cytokines play roles in regulating the development and progression of PDR. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin, Tianjin, China  Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas 1. Abu El-Asar AM, Al-Mezaine HS, Ola MS. Pathophysiology and management of diabetic retinopathy. Exp Rev Opthalmol 4:627-47, 2009. 2. Kowluru RA, Odenbach S. Role of interleukin-1beta in the pathogenesis of diabetic retinopathy. Br J Ophthalmol 88:1343-7, 2004. 3. Kern TS. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp Diabetes Res 95103, 2007. 4. Koskela UE, Kuusisto SM, Nissinen AE, Savolainen MJ, Liinamaa MJ. High vitreous concentration of IL-6 and IL-8, but not of adhesion molecules in relation to plasma concentrations in proliferative diabetic retinopathy. Ophthalmic Res 49:108-14, 2013. 5. Kim SJ, Kim S, Park J, Lee HK, Park KS, Yu HG, et al. Differential expression of vitreous proteins in proliferative diabetic retinopathy. Curr Eye Res 31:231-40, 2006. 6. Hernández C, Segura RM, Fonollosa A, Carrasco E, Francisco G, Simó R. Interleukin-8, monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy. Diabetic Med 22:719-22, 2005. 7. Koleva-Georgieva DN, Sivkova NP, Terzieva D. Serum inflammatory cytokines IL-1beta, IL-6, TNF-alpha and VEGF have influence on the development of diabetic retinopathy. Folia Med (Plovdiv) 53:44-50, 2011. 8. Lee JH, Lee W, Kwon OH, Kim JH, Kwon OW, Kim KH, et al. Cytokine profile of peripheral blood in type 2 diabetes mellitus patients with diabetic retinopathy. Ann Clin Lab Sci 38:361-7, 2008. 9. El-Ghrably IA, Dua HS, Orr GM, Fisher D, Tighe PJ. Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy. Br J Ophthalmol 85:461-70, 2001. 10. Vincent JA, Mohr S. Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 56:224-30, 2007. 11. Kowluru RA, Odenbach S. Role of interleukin-1beta in the development of retinopathy in rats: Effect of antioxidants. Invest Ophthalmol Vis Sci 45:4161-6, 2004. 12. Krady JK, Basu A, Allen CM, Xu Y, LaNoue KF, Gardner TW, et al. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 54:1559-65, 2005. 13. Zhou J, Wang S, Xia X. Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathy. Curr Eye Res 37:416-20, 2012. 14. Paine SK, Sen A, Choudhuri S, Mondal LK, Chowdhury IH, Basu A, et al. Association of tumor necrosis factor alpha, interleukin 6, and interleukin 10 promoter polymorphism with proliferative diabetic retinopathy in type 2 diabetic subjects. Retina 32:1197-203, 2012. 15. Hernández C, Segura RM, Fonollosa A, Carrasco E, Francisco G, Simó R. Interleukin-8, monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy. Diabet Med 22:719-22, 2005. 16. Mycliwiec M, Zorena K, Balcerska A, Mycliwska J, Lipowski P, Raczyflka K. The activity of N-acetyl-beta-D-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children. Clin Biochem 39:851-6, 2006. 17. Canataroglu H, Varinli I, Ozcan AA, Canataroglu A, Doran F, Varinli S. Interleukin (IL)-6, interleukin (IL)-8 levels and cellular composition of the vitreous humor in proliferative diabetic retinopathy, proliferative vitreoretinopathy, and traumatic proliferative vitreoretinopathy. Ocul Immunol Inflamm 13:375-81, 2005. Other articles written by the author Hua Yan Otros artículos de Hua Yan Chen S, Zhou S, Zang K, Kong F, Liang D, Yan H. CD73 expression in RPE cells is associated with the suppression of conventional CD4 cell proliferation. Exp Eye Res 127:26-36, 2014. 2. Cui J, Liu Y, Zhang J, Yan H. An experimental study on choroidal neovascularization induced by Krypton laser in rat model. Photomed Laser Surg 32(1):30-6, 2014. 3. Wang J, Chen S, Jiang F, You C, Mao C, Yu J, Han J, Zhang Z, Yan H. Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomy. PLoS One 16;9(10):e110531, 2014. 4. Zheng H, Zhang Z, Luo N, Liu Y, Chen Q, Yan H. Increased Th17 cells and IL 17 in rats with traumatic optic neuropathy. Mol Med Rep 10(4):1954-8, 2014. 5. Yao B, Zhao Q, Yan H, Chen F, Liu L. Correlation between the reduced circulating endothelial progenitor cell counts and elevated intraocular pressure-induced retinal ganglion cell apoptosis. Curr Eye Res 15:1-10, 2014. 6. Ying W, Zhigang Y, Caiyun Y, Jindong H, Haiyan L, Zhuhong Z, Hua Y. Overexpression p21WAF1/CIP1 in suppressing retinal pigment epithelial cells and progression of proliferative vitreoretinopathy via inhibition CDK2 and cyclin E. BMC Ophthalmology 25;14:144, 2014. 7. Zhang W, Yan H. Dysfunction of circulating endothelial progenitor cells in type 1 diabetic rats with diabetic retinopathy, Graefes Arch Clin Exp Ophthalmol 251(4):1123-31, 2013. 8. Han J, Yuan Z, Yan H. Inhibitory effect of adenoviral vector-mediated delivery of p21(WAF1/CIP1) on retinal vascular endothelial cell proliferation and tube formation in cultured rhesus monkey cells (RF/6A). Curr Eye Res 38(6):670-3, 2013. Yan H, Cui J, Wang Y, Yu Y. Comparison of the effects between Intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor on suppressing choroidal neovascularization in rats. Ophthalmic Res 49(2):81-9, 2013. SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
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Information about the full text Acerca del trabajo completo Roles of Elevated Intravitreal IL-1Beta and IL-10 Levels in Proliferative Diabetic Retinopathy Author / Autor Hua Yan1, Mao Chunjie2 2 Doctor, Department Of Ophthalmology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Tianjin-300052, Ch Access to the original source Indian Journal of Ophthalmology URL of Abstract: / URL del abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131322/ siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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