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Shih-Che Huang describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo Bile acid receptor as potential therapeutic target BILE ACIDS RELAX LOWER ESOPHAGEAL SPHINCTER VIA G-PROTEIN COUPLED RECEPTORS Bile acids help fat digestion in the gastrointestinal tract. Bile acids can also act as hormones. Activation of G-protein coupled bile receptors by bile acids relaxes gastrointestinal muscles including the lower esophageal sphincter. The bile acid receptor might be a potential therapeutic target for treating gastro-esophageal reflux disease. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación  Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas Fryer RM, Ng KJ, Nodop Mazurek SG, et al. G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism. J Pharmacol Exp Ther 348:421-431, 2014. Huang SC. Bile acids cause relaxation of the lower esophageal sphincter through G-protein-coupled bile acid receptors. Tzu Chi Med Journal 25:90-93, 2013. Kuipers F, Bloks VW, Groen AK. Beyond intestinal soap-bile acids in metabolic control. Nat Rev Endocrinol 10:488-498, 2014. McQuaid KR, Laine L, Fennerty MB, Souza R, Spechler SJ. Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia. Aliment Pharmacol Ther 34:146-165, 2011. Taegtmeyer AB, Haschke M, Tchambaz L, et al. A study of the relationship between serum bile acids and propranolol pharmacokinetics and pharmacodynamics in patients with liver cirrhosis and in healthy controls. PLoS One 9:e97885, 2014. Other articles written by the author Shih-Che Huang Otros artículos de Shih-Che Huang 1. Chang BS, Chang JC, Huang SC. Proteinase-activated receptors 1 and 2 mediate contraction of human oesophageal muscularis mucosae. Neurogastroenterol Motil. 2010;22:93-7, e32. 2. Huang SC. Endothelin A receptors mediate relaxation of guinea pig internal anal sphincter through cGMP pathway. Neurogastroenterol Motil. 2010;22:1009-1, e264. 3. Huang SC. Dendroaspis natriuretic peptide is the most potent natriuretic peptide to cause relaxation of lower esophageal sphincter. Regul Pept. 2011;167:246-9. 4. Huang SC. Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. Life Sci. 2011;88:819-24. 5. Huang SC. Effects of trypsin, thrombin and proteinase-activated receptors on guinea pig common bile duct motility. Regul Pept. 2012;179:1-5. 6. Lee MC, Yang YC, Chen YC, Huang SC. Muscarinic receptor M(3) mediates human gallbladder contraction through voltage-gated Ca(2+) channels and Rho kinase. Scand J Gastroenterol. 2013;48:205-12. 7. Huang SC. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014;189:46-50. SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
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Information about the full text Acerca del trabajo completo Bile Acids Cause Relaxation of the Lower Esophageal Sphincter Through G-Protein-Coupled Bile Acid Receptors Author / Autor Shih-Che Huang1 1 Md, Phd, Department Of Internal Medicine, E-da Hospital, And School Of Medicine, I-shou University, Kaohsiung, Taiwan, Kaohsiung, Taiwán (Republica Nacionalista China), Professor Article URL: / URL del artículo: http://www.tcmjmed.com siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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