Crónicas de autores

Rosa Del Camp *

Autor invitado por SIIC

Ayuda a entender las infecciones crónicas

TIPIFICACIÓN MOLECULAR DE BACTERIAS

En un único paciente hemos analizados cepas iguales por PFGE y diferentes por MLST. Esto fue debido a una mutación en el gen mutL.

*Rosa Del Camp
describe para SIIC los aspectos relevantes de su trabajo
EMERGENCE OF A MUTL CAUSING MULTILOCUS SEQUENCE TYPING-PULSED-FIELD GEL ELECTROPHORESIS DISCREPANCY AMONG PSEUDOMONAS AERUGINOSA ISOLATES FROM A CYSTIC FIBROSIS PATIENT
Journal of Clinical Microbiology,
50(5):1777-1778 May, 2012

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Hospital Universitario Ramón y Cajal, Madrid, España
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Referencias bibliográficas
1. Ban C, Yang W. 1998. Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell 95:541–552.
2. Ciofu O, Mandsberg LF, Bjarnsholt T, Wassermann T, Høiby N. 2010. Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants. Microbiology 156:1108–1119.
3. Cramer N, et al. 2011. Microevolution of the major common Pseudomonas aeruginosa clones C and PA14 in cystic fibrosis lungs. Environ. Microbiol. 13:1690–1704.
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8. Logan C, et al. 2012. Genetic relatedness of Pseudomonas aeruginosa isolates among a paediatric cystic fibrosis patient cohort in Ireland. J. Med. Microbiol. 61:64–70.
9. Maatallah M, et al. 2011. Population structure of Pseudomonas aeruginosa from five Mediterranean countries: evidence for frequent recombination and epidemic occurrence of CC235. PLoS One 6:e25617.
10. Oliver A, Baquero F, Blázquez J. 2002. The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants. Mol. Microbiol. 43:1641–1650.
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12. Waine DJ, Honeybourne D, Smith EG, Whitehouse JL, Dowson CG. 2009. Cross-sectional and longitudinal multilocus sequence typing of Pseudomonas aeruginosa in cystic fibrosis sputum samples. J. Clin. Microbiol. 47:3444–3448.
13. Woodford N, Turton JF, Livermore DM. 2011. Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. FEMS Microbiol. Rev. 35:736–755.
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