XIMELAGATRAN: ACTUALIZACION SOBRE EL MECANISMO DE ACCION Y EL DESARROLLO CLINICO DEL PRIMER INHIBIDOR DIRECTO DE LA TROMBINA POR VIA ORAL
Columnista Experta de SIIC Sarich, Troy
en colaboración con
Stig Boström , PhD Professor. AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden; Ulf Eriksson , PhD. AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden; Michael Wolzt , MD Clinical Pharmacology, Allgemeines Krankenhaus Wien, Medical University of Vienna, Vienna, Austria; Christer Mattsson , PhD. AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden
Fecha de aprobación: 30 de junio, 2004
Primera edición en siicsalud:
18 de marzo, 2005
Sección Artículos originales,
subsección
Expertos de Iberoamérica,
página
/des/expertocompleto.php/69027
Especialidad principal:
Farmacología
Hematología
Especialidades relacionadas:
Bioquímica,Cardiología,Diagnóstico por Laboratorio,Medicina Farmacéutica,Medicina Interna,
Boström SL, Hansson GF, Sarich TC, Wolzt M. The inhibitory effect of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma, Thrombosis Research 113(113):85-91
Sarich TC, Johansson S, Schutzer KM, Wall U, Kessler E, Teng R, Eriksson UG. The pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor, are unaffected by a single dose of alcohol, Journal of Clinical Pharmacology 44(44):388-393
Schutzer KM, Wall U, Lonnerstedt C, Ohlsson L, Teng R, Sarich TC, Eriksson UG. Bioequivalence of ximelagatran, an oral direct thrombin inhibitor, as whole or crushed tablets or dissolved formulation, Current Medical Research and Opinion 20(20):325-331
Wolzt M, Boström SL, Svensson M, Wahlander K, Grind M, Sarich TC. Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation, Pathophysiology of Haemostasis and Thrombosis 33(33):68-74
Sarich TC, Osende JI, Eriksson UG, Fager GB, Eriksson-Lepkowska M, Ohlsson L, Carlsson S, Wahlander K, Gustafsson D, Badimon JJ. Acute antithrombotic effects of ximelagatran, an oral direct thrombin inhibitor, and r-hirudin in a human ex vivo model of arterial thrombosis, Journal of Thrombosis and Haemostasis 1(1):999-1004
Sarich, Troy
